
The 16th century was the beginning of the Decline of the Republic of Venice.
In 1516 the first Jewish Ghetto founded in Venice (World First).
Cyprus had been conquered by Venice since 1489.
Pope Julius II initiated the conquering of Venice. All neighbouring powers joined in this League of Cambrai in 1508.
Venice was defeated at the battle of Agnadello on 14 May 1509, in the Ghiara d'Adda.
In 1539 the Turkish fleet attacked and destroyed Limassol.
By 1563, the population of Venice had dropped to about 168,000 people.
The Turks struck again in 1570, this time with a full-scale invasion rather than a raid. Under the command of Mustafa Pasha, around 60,000 troops, including cavalry and artillery, landed and laid siege to Nicosia. 20,000 Nicosian Greeks and Venetians were put to death, and every church, public building, and palace was looted.
As early as 1423, the Ottoman Empire started sea campaigns, when it waged a seven year war with the Venetian Republic over maritime control of the Aegean Sea and the Adriatic Sea.
In 1489, the first year of Venetian control of Cyprus, Turks attacked the Karpasia Peninsula, pillaging and taking captives to be sold into slavery.
16th Century Venice:

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